Warning: require_once(/Ortopedia/includes/defines.php) [function.require-once]: failed to open stream: No such file or directory in /Ortopedia/index.php on line 21

Fatal error: require_once() [function.require]: Failed opening required '/Ortopedia/includes/defines.php' (include_path='.:/:/usr/local/php/pear5') in /Ortopedia/index.php on line 21